Medications are more frequently prescribed for those with secondary Raynaud’s syndrome. Calcium-channel blockers, which relax smooth muscle and dilate the small blood vessels, are usually the chosen medication. These drugs have been found to decrease the frequency and severity of attacks in about two-thirds of patients who have primary and secondary Raynaud’s syndrome. These drugs also can help heal skin ulcers on the fingers or toes.

Other patients have found relief with drugs called alpha blockers that counteract the actions of norepinephrine, a hormone that constricts blood vessels. Some doctors prescribe a nonspecific vasodilator (drug that relaxes blood vessels), such as nitroglycerine paste, which is applied to the fingers, to help heal skin ulcers. Patients should keep in mind that the treatment for Raynaud’s syndrome is more management-oriented, rather than treatment oriented, as known treatment methods are not always successful. Often, patients with the secondary form will not respond as well to treatment as those with the primary form of the disorder.

Patients may find that one drug works better than another. Some people may experience side effects that may require stopping the medication. Some people may develop tolerance to certain drugs over time. Women of childbearing age should know that the medications used to treat Raynaud’s syndrome may affect the growing foetus. Therefore, women who are pregnant or are trying to become pregnant should avoid taking these medications if possible.